After a disappointing start to the campaign, Zinedine Zidane's side appear to have hit form at precisely the right time.
Last week's first leg victory put them within striking distance of the Champions League final four - and they followed it up with an equally important victory in the El Clasico, leaving them now just one point behind their cross-city rivals and current league leaders Atletico with eight games to play.
Wednesday will mark Real Madrid's third-ever Anfield visit. Liverpool fans will be hoping the scoreline will be a closer reflection to 2009's 4-0 win, as opposed to 2014's 0-3 defeat.
In UEFA Champions League history, Real Madrid have progressed in 15 out of 16 knock-out matches where they've held a 2+ goal lead after the first-leg. The only side to overturn such a lead was Monaco in the 2003-04 season when the French side went on to reach the final.